Elliot Temple | Permalink | Messages (5)

Aubrey de Grey Discussion, 5

I discussed epistemology and cryonics with Aubrey de Grey via email. Click here to find the rest of the discussion. Yellow quotes are from Aubrey de Grey, with permission. Bluegreen is me, red is other.
I’ve been completely unable to get my head around what [David Deutsch] says about explanations, and you’ve reawakened my confusion.

Essentially, I think I agree that there are no probabilities in the past, which I think is your epistemological point, but I don’t see how that matters in practice - in other words, how we can go wrong by treating levels of confidence as if they were probabilities.
That thing about the past isn't my point. My point is there are probabilities of events (in physics), but there are no probabilities that ideas are true (in epistemology). E.g. there is a probability a dice roll comes up 4, but there isn't a probability that the Many-Worlds Interpretation in physics is true – we either do or don't live in a multiverse.

So a reference to "probability" in epistemology is actually a metaphor for something else, such as my confidence level that the Many-Worlds Interpretation is true. This kind of metaphorical communication has caused confusion, but isn't a fundamental problem. It can be understood.

The bigger problem is that using confidence levels is also a mistake.

Below I write brief replies, then discuss epistemology fundamentals after.
The ultimate purpose of any analysis of this kind - whether phrased in terms of probabilities, parsimony of hypotheses, quality of explanations, whatever - is surely to determine what one should actually do in the face of incomplete information.
I agree with decision making as a goal, including decisions about mental actions (e.g. deciding what to think about a topic).
So, when you say this:
I'm guessing you may have in mind an explanation something like, "We don't know how much brain damage is too much, and can model this uncertainty with odds." But someone could say the same thing to defend straight freezing or coffins, as methods for later revival, so that can't be a good argument by itself.
I don’t get it. The amount of damage is less for vitrification than for freezing and less for freezing than for burial. So, the prospect of revival by a given method is less plausible (why not less “probable”?) for burial than freexing than vitrification.
I explain more about my intended point here at footnote [1] below.

I agree that changing "probable" to "plausible" doesn't change much. My position is a different epistemology, not a terminology adjustment.
But, when we look at a specific case (e.g. reviving a vitrified person by melting, or a frozen person by uploading), we need to look at all the evidence that we may think bears on it - the damage caused by fracturing, for example, and on the other side the lack of symptoms exhibited by people whose brain has been electrically inactive for over an hour due to low temperature. Since we know we’re working in the context of incomplete information, and since we need to make a decision, our only recourse is to an evaluation of the quality of the explanations (as you would say it - I rather prefer parsimony of hypotheses but I think that’s pretty nearly the same thing).
I actually wouldn't say that.

My approach is to evaluate explanations (or more generally ideas) as non-refuted or refuted. One or the other. This is a boolean (two-valued) evaluation, not a quantity on a continuum. Examples of continuums would be amount of quality, amount of parsimony, confidence level, or probability.

These boolean evaluations, while absolute (or "black and white") in one sense, are tentative and open to revision.

In short: either there is (currently known) a criticism of an idea, or there isn't. This categorizes ideas as refuted or not.

Criticisms are explanations of flaws ideas have – explanations of why the idea is wrong and not true. (The truth is flawless.)

Issues like confidence level aren't relevant. If you can't refute (explain a problem with) either of two conflicting ideas, why would you be more confident about one than the other?

When dealing with a problem, the goal is to get exactly one non-refuted idea about what to do. Then it's clear how to act. Act on the idea with no known flaws (criticisms) or alternatives.

Since this idea has no rivals, amount of confidence in it is irrelevant. There's nothing else to act on.

There are complications. One is that criticisms can be criticized, and ideas are only refuted by criticisms which are, themselves, non-refuted. Another is how to deal with the cases of having multiple or zero non-refuted ideas. Another is that parsimony or anything else is relevant again if you figure out how to use it in a criticism in order to refute something in a boolean way.
And the thing is, you haven’t proposed a way to rank that quality precisely, and I don’t think there is one. I think it is fine to assign probabilities, because that’s a reflection of our humility as regards the fidelity with which we can rank one explanation as better than another.
I think there's no way to rank this, precisely or non-precisely. Non-refuted or refuted is not a ranking system.

I don't think rankings work in epistemology. The kind of rankings you're talking about would use a continuum, not a boolean approach.

I provide an explanation about rankings at footnote [2], with cryonics examples.

The fundamental problem in epistemology is: ideas conflict with each other. How should people resolve these conflicts? How should people differentiate and choose between ideas?

One answer would be: whenever two ideas conflict, at least one of them is false. So resolve conflicts by rejecting all false ideas. But humans are fallible and have incomplete information. We don't have direct access to the truth. So we can't solve epistemology this way.

The standard answer today, accepted by approximately everyone, is so popular it doesn't even have a name. People think of it as epistemology, rather than as a particular school of epistemology. It involves things like confidence levels, parsimony, or other ranking on continuums. I call it "justificationism", because Popper did, and because of the mistaken but widespread idea that "knowledge is justified, true belief".

Non-justificationist epistemology involves differentiating ideas with criticism (a type of explanation) and choosing non-refuted ideas over refuted ideas. Conflicts are resolved by creating new ideas which are win/win from the perspectives of all sides in the conflict.

Standard "Justificationism" Epistemology

This approach involves choosing some criteria for amount of goodness (on a continuum) of ideas. Then resolving conflicts by favoring ideas with more goodness (a.k.a. justification).

Example criteria of idea goodness: reasonableness, logicalness, how much sense an idea makes, Occam's Razor, parsimony, amount and quality of supporting evidence, amount and quality of supporting arguments, amount and quality of experts who agree, degree of adherence to scientific method, how well it fits with the Bible.

The better an idea does on whichever criteria a particular person accepts, the higher goodness he scores (a.k.a. ranks) that idea as having. If he's a fallibilist, this scoring is his best but fallible judgment using what he knows today; it can be revised in the future.

There are also infallibilists who think some arbitrary quantity of goodness (justification) irreversibly changes an idea from non-good (non-justified) to good (justified). In other words, once you prove something, it's proven, the end. Then they say it's impossible for it to ever be refuted. Then when it's refuted, they make excuses about how it was never really proven in the first place, but their other ideas still really are proven. I won't talk about infallibilism further.

This goodness scoring is discussed in many ways like: justification, probability, confidence, plausibility, status, authority, support, verification, confirmation, proof, rationality and weight of the evidence.

Individual justificationists vary in which of these they see as good. Some reject the words "authority" or even "justification".

So both the criteria of goodness, and what they think goodness is, vary (which is why I use the very generic term "goodness"). And justificationists can be fallibilists or infallibilists. They can also be inductivists, or not and empiricists or not. Like they could think inductive support should raise our opinion of how good (justified) ideas are, but alternatively they could think induction is a myth and only other methods work.

So what's the same about all justificationists? What are the common points?

Justificationists, in some way, try to score how good ideas are. That is their method of differentiating ideas and choosing between ideas.

One more variation: justifications don't all use numerical scores. Some prefer to say e.g. "pretty confident" instead of "60% confident", perhaps because they think 60% is an arbitrary number. If someone thought the 60% was literal and exact, that'd be a mistake. But if it's understood to be approximate, then using an approximate number makes no fundamental difference over an approximate phrase. Using a number can be a different way to communicate "pretty confident".

Popper refuted justificationism. This has been mostly misunderstood or ignored. And even most Popperians don't understand it very well. It's a big topic. I'll briefly indicate why justificationism is a mistake, and can explain more if you ask.

Justificationism is a mistake because it fundamentally does not solve the epistemology problem of conflicts between ideas. If two ideas conflict, and one is assigned a higher score, they still conflict.

Other Justificationism Problems

Justificationism is anti-critical because instead of answering a criticism, a justificationist can too easily say, "OK, good point. I've lowered my goodness (justification) score for this idea. But it had a lead. It's still winning." (People actually say it less clearly.) In this way, many criticisms aren't taken seriously enough. A justificationist may have no counter-argument, but still not change his mind.

Justificationism is anti-explanatory, because scores aren't explanations.

Another issue is combining scores from multiple factors (such as parsimony and scientific evidence. Or evidence from two different kinds of experiments) to reach a single final overall score. This doesn't work. A lot about why it doesn't work is explained here: http://www.newyorker.com/magazine/2011/02/14/the-order-of-things

One might try using only one criterion to avoid combining scores. But that's too limited. And then you have to ignore criticism. For example, if the one single criterion is parsimony, the score can't be changed just because someone points out a logical contradiction, since that isn't a parsimony issue. This single criterion approach isn't popular.

There's more problems, I just wanted to indicate a couple.

Popper Misunderstandings

A common misunderstanding is that Popper was proposing new criteria for goodness (justification) such as (amount of) testability, severity of tests passed, how well an idea stands up to criticism, (amount of) corroboration, and (amount of) explanatory power. This is then dismissed as not making a big difference over the older criteria. DD's (David Deutsch's) "hard to vary" can also be misinterpreted as a criterion of goodness (justification).

That's not what Popper was proposing.

Another misunderstanding is that Popper proposed replacing positive justifying criteria with a negative approach. In this view, instead of figuring out which ideas are good by justifying, we figure out which ideas are bad by criticizing (anti-justifying).

This would not be a breakthrough. Some justificationists already viewed justification scores as going both up and down. There can be criteria for badness in addition to goodness. And it makes more sense to have both types of criteria than to choose one exclusively.

This wasn't Popper's point either.

Non-Justificationist Epistemology

This is very hard to explain.

Fundamentally, the way to (re)solve a conflict between ideas is to explain a (win/win) (re)solution.

This may sound vacuous or trivial. But it isn't what justificationism tries to do.

It's similar to BoI's point that what you need to solve a problem is knowledge of how to solve it.

How are (re)solutions found? There's many ways to approach this which look very different but end up equivalent. I'm going to focus on an arbitration model.

Think of yourself as the arbiter, and the conflicting ideas as the different sides in the arbitration. Your goal is not to pick a winner. That's what justificationism does. Your goal as arbiter, instead, is to resolve the conflict – help the sides figure out a win/win outcome.

This arbitration can involve any number of sides. Let's focus on two for simplicity.

Both sides in the conflict want some things. Try to figure out a new idea so that they both get what they want. E.g. take one side's idea and modify it according to some concerns of the other side. If you can do this so everyone is happy, you have a non-refuted idea and you're done.

This can be hard. But there are techniques which make solutions always possible using bounded resources.

DD would call this arbitration "common preference finding", and has written a lot about it in the context of his Taking Children Seriously. He's long said and argued e.g. that "common preferences are always possible". A common preference is an outcome which all sides prefer to their initial preference – wholeheartedly with no regrets, downsides, compromises or sacrifices. It's strictly better than alternatives, not better on balance.

In BoI, DD writes about problems being soluble – and what he means by solutions is strictly win/win solutions which satisfy all sides in this sort of arbitration.

An arbitration tool is new ideas (which are usually small modifications of previous ideas). For example, take one side's idea but modify a few parts to no longer conflict with what the other side wants.

As long as every side wants good things, there is a solution like this to be found. Good things don't inherently conflict.

Sometimes sides want bad things. This can either be an honest mistake, or they can be evil or irrational.

If it's an honest mistake, the solution is criticism. Point out why it seems good but is actually bad. Point out how they misunderstood the implications and it won't work as intended. Or point out a contradiction between it and something good they value. Or point out an internal contradiction. Analyze it in pieces and explain why some parts are bad, but how the legitimate good parts can be saved. When people make honest mistakes, and the mistake is pointed out, they can change their mind (usually only partially, in cases where only part of what they were saying was mistaken).

How can a side be satisfied by a criticism/refutation? Why would a side want to change its mind? Because of explanations. A good criticism points out a mistake of some kind and explains what's bad about it. So the side can be like, "Oh, I understand why that's bad now, I don't want that anymore." Good arguments offer something better and make it accessible to the other side, so they can see it's (strictly) better and change their mind with zero regrets (conflict actually resolved).

If there is an evil or irrational mistake, things can go wrong. Short answer: you can't arbitrate for sides which don't want solutions. You can't resolve conflicts with people who want conflict. Rational epistemology doesn't work for people/sides/ideas who don't want to think rationally. But one must be very careful to avoid declaring one's opponents irrational and becoming an authoritarian. This is a big issue, but I won't discuss it here.

Arbitration ends when there's exactly one win/win idea which all sides prefer over any other options. There are then no (relevant to the issue) conflicts of ideas. (DD would say no "active" conflicts). Put another way, there's one non-refuted idea.

Arbitration is a creative process. It involves things like brainstorming new ideas and criticizing mistakes. Creative processes are unpredictable. A solution could take a while. While a solution is possible, what if you don't think of it?

Reasonable sides in the arbitration can understand resource limits and lower expectations when arbitration resources (like time and creative energy) run low. They can prefer this, because it's the objectively best thing to do. No reasonable party to an arbitration wants it to take forever or past some deadline (like if you're deciding what to do on Friday, you have to decide by Friday).

When the sides in a conflict are different people, the basic answer is the more arbitration gets stuck, the less they should try to interact. If you can't figure out how to interact for mutual benefit, go your separate ways and leave each other alone.

With a conflict between ideas in one person, it's trickier because they can't disengage. One basic fact is it's a mistake to prefer anything that would prevent a solution (within available resources) – kind of like wanting the impossible. The full details of always succeeding in these arbitrations, within resource limits, are a big topic that I won't include here.

How do justificationists handle arbitrations? They hear each side and add and subtract points. They tally up the final scores and then declare a winner. The primary reason the loser gets for losing is "because you scored fewer points in the discussion". The loser is unsatisfied, still disagrees, and there's still a conflict, so the arbitration failed.

Here's a different way to look at it. Each side in arbitration tries to explain why its proposal is ideal. If it can persuade the other side, the conflict is resolved, we're done. If it can't, the rational approach is to treat this failure to persuade as "huh, I guess I need better ideas/explanations" not as "I have the truth, but the other guy just won't listen!"

In other words, if either side has enough knowledge to resolve the conflict, then the conflict can be resolved with that knowledge. If neither side has that, then both sides should recognize their ideas aren't good enough. Both sides are refuted and a new idea is needed. (And while brilliant new ideas to solve things are hard to come by, ideas meeting lowered expectations related to resource limits are easier to create. And it gets easier in proportion to how limited resources are, basically because it's a mistake to want the impossible.)

Justificationism sees this differently. It will try to pick a winner from the existing sides, even when (as I see it) they aren't good enough. As I see it, if the existing sides don't already offer a solution (and only a fully win/win outcome is a solution), then the only possible way to get a solution is to create a new idea. And if any side doesn't like it (setting aside evil, irrationality, not wanting a solution, etc), then it isn't a solution, and no amount of justifying how great it is could change that.


To relate this back to some of the original topics:

The arbitration model doesn't involve confidence levels or probabilities. Ideas have boolean status as either win/win solutions (non-refuted), or not (refuted), rather than a score or rank on a continuum. Solutions are explanations – they explain what the solution is, how it solves the problem(s), what mistakes are in all attempted criticisms of this solution, why it's a mistake to want anything (relevant) that this solution doesn't offer, why the things the solution does offer should be wanted, and so on. Explanation is what makes everything work and be appealing and allows conflicts to be resolved.

Final Comments

I don't expect you to understand or agree with all of this. Perhaps not much, I don't know. To discuss hard issues well requires a lot of back-and-forth to clear up misunderstandings, answer questions and objections, etc. Understanding has to be created iteratively (Popper would say "gradually" or "piecemeal").

I am open to discussing these topics. I am open to considering that I may be wrong. I wouldn't want a discussion to assume a conclusion from the start. I tried to explain enough to give some initial indication of what my epistemology is like, and some perspective about where I'm coming from.

Footnotes

[1]

My point was, whatever your method for preserving bodies, you could assign it some odds, arbitrarily. You could say cremation causes less damage than shooting bodies into the sun, so it has better revival odds. And then pick a small number for a probability. You need to have an argument regarding vitrification that couldn't be said by someone arguing for cremation, burial or freezing.

There should be something to clearly, qualitatively differentiate cryonics from alternatives like cremation. Like it should differentiate vitrification not as better than cremation to some vague degree, but as actually on a different side of an reasonably explained might-work/doesn't-work line.

Here's an example of how I might argue for cryonics using scientific research.

Come up with a measure of brain damage (hard) which can be measured for both living and dead people. Come up with a measure of functionality or intelligence for living people with brain damage (hard). Find living brain damaged people and measure them. Try to work out a bound, e.g. people with X or less brain damage (according to this measure of damage) can still think OK, remember who they are, etc.

Vitrify some brains or substitutes and measure damage after a suitable time period. Compare the damage to X.

Measure damage numbers for freezing, burial and cremation too, for comparison. Show how those methods cause more than X damage, but vitrification causes less than X damage. Or maybe the empirical results come out a different way.

Be aware that when doing all this, I was using many explanations as unconscious assumptions, background knowledge, explicit premises, and so on. Expose every part of this stuff to criticism, and for each criticism write an explanation addressing it or modify my view.

Then someone would be in a position to make a non-arbitrary claim favorable to cryonics.

This is not the only acceptable method, it's one example. If you could come up with some other method to get some useful answers, that's fine. You can try whatever method you want, and the only judge is criticism.

But something I object to is assigning probabilities, or any kind of evaluations, without a clear method and explanation of it. (E.g. where does your 10% for cryo come from? Where does anyone's positive evaluation come from?)

I don't think it's reasonable for Alcor or CI to ask people to pay 5-6 figures without first having a good idea about how to judge today's cryonics (like my example method). And from a decision making perspective, I expect people asking for lots of money – and saying they can perform a long term service for me in a reliable way – should have some basic competence and reasonable explanations about their stuff. But instead they put this on their website:

http://www.alcor.org/Library/html/CaseForWholeBody.html

It offers a variation on Pascal's Wager to argue for full-body cryo over neuro (basically, get full body just in case it's necessary for cryo to work). No comment is made on whether we should also believe in God due to Pascal's Wager. And it states:
Now, what if we would relax our assumptions a little and allow for some degree of ischemia or brain damage during cryopreservation? It strikes us that this further strengthens the case for whole body cryopreservation because the rest of the body could be used to infer information about the non-damaged state of the brain, an option not available to neuropatients.
No. I'm guessing you also disagree with this quote, so I won't argue unless you ask.

There are some complications like maybe Alcor is confused but today's cryonics works anyway. I won't go into that now.


[2]

We can, whenever we want, create ranking systems which we think will be useful for some purpose (somewhat like defining new units of measurement, or defining new categories to categorize stuff with).

The judge of these inventions is criticism. E.g. someone might criticize a ranking system by pointing out why it isn't effective for its intended purpose.

Concretely, we could rank body preservation methods by the amount of brain damage after 10 years. Then, in that system, we'd rank vitrification > freezing > burial > cremation.

Whether this is useful depends on context (which Popper calls the problem situation). What problem(s) are we trying to solve? Do we have a non-refuted idea for how to use the ranking in any solutions?

Our example ranking system has some relevance to people who consider brain damage important, but not to people who believe the goal should be to preserve the soul by using the most holy methods. They'd want to rank by holiness, and might rank vitrification last.

This is important because the rankings only matter in the context of some explanations of how they matter and for what (which must deal with criticism).

So ranking is secondary to explanation. It can't come first. This makes ranking unsuited for dealing with epistemology issues such as how to decide which explanations to accept in the first place.

In summary, we can make something up, argue why it's effective for a purpose, and if our argument is successful then we can use it for that purpose. This works with rankings and many other things.

But this is different than epistemology rankings, like trying to rank how good ideas are, or how probable, or how high quality of explanations they are.

Or put another way: to rank those things, you would have to specify how that ranking system worked, and explain why the results are useful for what. That's been tried a lot. I don't think those attempts have succeeded, or can succeed.

Continue reading the next part of the discussion.

Elliot Temple | Permalink | Message (1)

Aubrey de Grey Discussion, 4

I discussed epistemology and cryonics with Aubrey de Grey via email. Click here to find the rest of the discussion. Yellow quotes are from Aubrey de Grey, with permission. Bluegreen is me, red is other.
I can’t point you to anything better than what is posted at Alcor’s and CI’s sites, no. Instead let’s look at what you say below. Sure there is an objective, impersonal truth of the matter about the current state of any particular technology. The question is whether what we do with that truth should be similarly objective and impersonal, and I don’t think it should. I believe it is OK for people to have different values and priorities, whether it’s concerning the merits of tomato ketchup or the value of life. Therefore, I believe there is a range of legitimate opinions about the justifiability of a given course of action. For sure that range will be finite, i.e. there will be cases where people are not adopting a policy that is consistent with their other beliefs and will be resistant to recognising that fact, but that doesn’t change that fact that there is still that (finite) room for legitimate agreement to disagree. Cryonics is a rather extreme case, because its basis in the prospect of revival in the rather distant future entails so much uncertainty as to the pros and cons. I value my and others’ lives very highly, and I consider it quite likely that the future will be a progressively more fulfilling place to be, so I think signing up for cryopreservation makes sense even if one evaluates the chance of being revived and being glad one had been is quite low (I would probably go as low as 1%, and I definitely think we’re up at at least 10% today, even taking into account the issues we’ve been discussing). But I don’t claim to have an objective, impersonal argument for that 1% - rather, if someone else values life less than I do and/or they are more pessimistic about human progress, and they conclude that their cutoff is 50%, they’re welcome to their opinion. No?
I agree about some scope for people to differ, though I don't think the reasonable range extends to not signing up for cryonics that is 50% likely to work, for people who can afford it.

I, too, value life very highly and expect the future to be dramatically better. I think concerns about e.g. overpopulation and running out of jobs are bad philosophy, both generally (problems are soluble, and we don't have to and shouldn't expect to know all future solutions today) and also I could give specific arguments on those two issues today. And I'm not worried that I might not be glad to be revived.

But we have a disagreement about methodology and epistemology, which comes up with your comments on percentages.

If I believed cryonics had even 1% odds in a meaningful sense, I'd sign up too. I value my life more than 100x the price. That's easy. An example of meaningful odds would be that for every 1000 people who sign up, 10 will be revived. But it doesn't work that way.

Explanations don't have percentage odds. It's important to look at issues in terms of good and bad explanations, and criticisms, not odds. (You may have some familiarity with this view from David Deutsch, including his criticisms of weighing ideas and of Bayesian epistemology.)

In FoR, DD uses the example idea that eating grass will cure a cold. Because there's no explanation of how grass does that, he explains that this empirically-scientifically testable idea isn't worth testing. It should be rejected just from the philosophical criticism that it lacks a good explanation.

It shouldn't be assigned a probability either. It's bad thinking, to be rejected as such, unless and until a new idea changes things.

Odds apply to issues like physical events. Odds are a reasonable way to think about the possibility of dying in a plane crash, or other cryo-incompatible deaths. Odds can even somewhat model problems like whether the cryo staff will make a mistake, or whether Alcor stays in business, though there are some problems there.

You could die in a plane crash, or not. It could go either way, so odds make some sense. But either current cryo methods (assume perfusion etc go well) preserve the necessary information, or they don't. That can't go either way, there's a fact of reality one way or the other.

The basic way odds are misused is there are multiple rival ideas, and rationally resolving the conflicts between them turns out to be difficult. So people seek ways to retreat from critical discussion and find a shortcut to a conclusion. E.g. a person favors an idea, and there is some idea which contradicts it which he can't objectively refute. Rather than say "I don't know", or figure out how to know, he assigns some odds to his idea, then lowers the odds for each criticism he doesn't refute. But the odds are completely arbitrary numbers and have no bearing on which ideas are correct.

Fundamentally, he's mistaken to take sides when two ideas contradict and he can't refute either one. Often this is done by bias, e.g. favoring the idea he thought of himself, or spent the last five years working on.

A starting point for a cryo explanation is that digging up graves to revive people won't work, due to brain damage (this could be explained in more detail I won't go into). There is no good explanation of how it could ever work. This bad explanation isn't worth scientific testing, and should not be assigned any odds.

Freezing people is better than coffins because it preserves more brain matter and prevents a lot of decay, but there's no good explanation that it would work either, because there's so much brain damage. All claims that it would work can be refuted by criticism (in the context of present knowledge). But vice versa doesn't apply: one could write an explanation of why straight freezing won't work for cryo, which would stand up to criticism. (Today. All these things are always tentative, and can be rethought if someone has a new idea.)

That is how issues should be resolved rationally. Get a situation with one explanation that survives criticism, and no rivals that do. Then, while one could still be mistaken, there is a non-arbitrary opportunity to accept the best current knowledge.

This is a Popperian view, which many people disagree with. They're wrong. And all of their arguments have known answers. I can answer any points you're interested in.

Changing subjects briefly, let's apply this to SENS. SENS is the best available knowledge on the issues it addresses, and which should not be dismissed by arbitrarily assigning it odds. Odds are a semi-OK approximation for whether specific already-understood SENS milestones will be done by a particular date, but are not an OK way to judge the truth of the core explanatory ideas of SENS. It's very important to look at SENS in terms of the proposed explanations and criticisms, and actually resolve the conflicts between different ideas (e.g. go through the criticisms of SENS and figure out concretely why each criticism is wrong, rather than be unable to objectively and persuasively answer some criticism but continue anyway. Note you are able to address EVERY criticism, which makes SENS good, as opposed to other ideas which don't live up to that important standard.)


Finally, today's vitrification processes cause less brain damage than freezing. But still lots of brain damage. So for the same main reason as before (lots of brain damage prevents reviving), cryonics won't work (until there's better technology).

Either this is the best available explanation, or there is information somewhere refuting it, or there is a rival for the best explanation that's also unrefuted. In each case, it's not a matter of odds, and this initial skeptical explanation regarding cryo I've given should stand as the best view on the matter unless there are certain kinds of specific relevant ideas (rivals, criticisms).


Behinds statements about odds, there usually are some explanations, but it'd be better to critically discuss them directly.

I'm guessing you may have in mind an explanation something like, "We don't know how much brain damage is too much, and can model this uncertainty with odds." But someone could say the same thing to defend straight freezing or coffins, as methods for later revival, so that can't be a good argument by itself.

To make a rational case for today's cryonics, there has to be some explanation about how much brain damage is too much, why that much, and how vitrification gets over the line (while, presumably, freezing and grave digging don't – though Alcor and CI don't seem to take that seriously, e.g. Alcor has dug up a corpse from a grave and stored it). Well, either there should be an explanation like I said above, or one explaining why that's the wrong way to look at it, and explaining something even better. Without good explanation, it's the grass cure for the cold again. You may also have in mind some further answers to these issues, but I can't guess them, and if they are good points that good content was omitted from the statement of odds.


Finally to put it another way: I don't think people should donate to SENS if the explanations in Ending Aging didn't exist (or equivalent prior material). Those good ideas make all the difference. Without those ideas, a claim that SENS might work (even with only 10% odds) would not suffice. And I don't think cryonics has the equivalent good explanations like SENS. (Though I'd be happy to be corrected if it does have that somewhere.)


If you are interested, I will write more explaining the philosophy here. Actually I did write more and deleted it, to keep things briefer. Epistemology, btw, is my chosen specialty. (I don't want any authority, I just think it's relevant to mention.)

Continue reading the next part of the discussion.

Elliot Temple | Permalink | Messages (4)

Aubrey de Grey Discussion, 3

I discussed epistemology and cryonics with Aubrey de Grey via email. Click here to find the rest of the discussion. Yellow quotes are from Aubrey de Grey, with permission. Bluegreen is me, red is other.
I merely claim that even today we are good enough at it that those who help the providers to help them have a good enough chance of revival that it makes sense to sign up, even if the cost compares with that of traditional health insurance.
Can you point me to writing which you think makes a correct, reasonably complete (across multiple sources is fine), and persuasive case for this reasonable chance of revival?

If I'm mistaken about this I'd like to find out (and sign up for cryonics), and I am willing put in the effort to find out.

I don't agree it's a matter of "personal evaluation". There's an objective, impersonal truth of the matter about the current state of cryonics. Just like whether SENS is currently a good idea is a matter of objective truth, not of personal evaluation. And various people who disagree with SENS are wrong.

I think people should only sign up for cryonics if adequate, objective, pro-cryonics arguments/explanations exist, which they can read and see why it makes sense, and which include answers to all important criticisms. And if that does exist, then it'd be a mistake to disagree anyway as some kind of personal matter. I (like Popper, Deutsch and Rand, who have explained some of the reasons) don't go for that "agree to disagree" and "personal evaluation" type stuff, which can be a way to dodge the rational pursuit of truth.
Let me conclude, however, by thanking you for your support of SENS and agreeing with you that SENS is plan A! It’s no accident that I work on SENS rather than on cryonics.

Cheers, Aubrey
Yeah. Best wishes.

Continue reading the next part of the discussion.

Elliot Temple | Permalink | Messages (0)

Aubrey de Grey Discussion, 2

I discussed epistemology and cryonics with Aubrey de Grey via email. Click here to find the rest of the discussion. Yellow quotes are from Aubrey de Grey, with permission. Bluegreen is me, red is other.
I don’t understand your logic here. I’m well aware of the issues you mention regarding the quality of Alcor’s and CI’s preservations, and I’ve never suggested that any current cryonics service is the same quality as regular medicine. Why do you think it would need to be that good to justify signing up?
I don't think it would have to equal regular medicine to be worthwhile. But the gap is big, and cryonics is expensive.

You said everyone should sign up for cryonics, for the same reason they have regular health insurance. This suggests that cryonics has traits seen with regular medicine, like being run pretty competently, providing value for cost, routinely providing good outcomes, and making your life better. Cryonics currently provides none of those.


To answer your question about what would justify signing up: First, I'd want cryonics organizations to be run in a competent and responsible way. Second, I'd want cryonics technology to improve enough to preserve brains well enough to optimistically expect the relevant information (about one's mind and ideas) to be preserved, and I would want cryonics organizations to provide quality persuasive intellectual explanations on this point. I think those two problems are deal breakers.

Regarding preservation, without staff errors, one big problem is fracturing – meaning breaks in the brain. Alcor's attitude seems to be that fracturing doesn't destroy information and nanotech can theoretically fix it because the breaks are smooth and the separated parts of the brain do not end up far apart. I'm not convinced; I think they'd need much better reasons to say this physical brain damage is OK and the relevant information still preserved. (I also think the idea of nanotech repairs is misguided. The focus should be on one day getting the information from the brain into a computer, not on fixing and reviving the original organic brain.) Fracturing is not the only serious technological problem.


If those two issues were fixed, I still would not recommend cryonics to "everyone", or most people, because it'd be a large financial burden for most people on Earth, in return for a long shot. Unless cryonics improved SPECTACULARLY, it wouldn't be worth signing up at a big cost to one's standard of living now. There's also the issue that the majority of people don't value life and don't want to live, in some pretty fundamental philosophical ways, as explained e.g. in Atlas Shrugged. Cryonics, like SENS, doesn't fit everyone's values and preferences.


It would also help if societal institutions handled cryonics better, e.g. if you could conveniently go a cryonics facility and kill yourself on site with staff present, rather than having them wait around for you to die (possibly suffering increasing brain damage from your disease in the meantime), wait for you to be pronounced legally dead, and perhaps deal with days of interference from regular medical personnel. Similarly, sometimes courts order people removed from cryo facilities. These things lower the chance of getting a good patient outcome, but I don't see fixing this as a strict requirement to sign up.

It would also be nice if I was a lot more convinced that Alcor and CI won't go out of business within the next 50 years, let alone 1000 years. Cryo preservation requires frequent maintenance and upkeep costs.
Two more points:

- A key feature that you don’t mention is that the poor preservations you list are cases where the individual did not do what I also strongly recommend, namely get themselves to the vicinity of their provider while their heart is still beating. Other cryonicists’ self-neglect isn’t a very good basis for one’s own decisions.
I don't think you read the cases closely. The Alcor case said he was in the Phoenix area, which is around 12 miles from Scottsdale, where Alcor is. It is the vicinity. Alcor refers to the "Scottsdale/Phoenix metropolitan area" on their website when explaining why they chose their location.

The reason for that bad outcome, and bad case report writing, was not due to location. For the CI case, it doesn't say what the reason for the bad outcome was, so we don't know if it had to do with location or not.

There are plenty of cases where people did everything right and got bad outcomes. There are even plenty of cases where cryo personnel irresponsibly caused bad outcomes. I include an example at the bottom of this email. There are, unfortunately, more examples available at the links I provided.
- As you say, current cryonics technology has a ways to go; but that’s another reason to sign up, since the more members Alcor and CI have, the more they can work to improve the technology.
Signing up for medical purposes, and for donation purposes, are different.

You said that, "... everyone should have a life insurance policy with Alcor or Cryonics Institute, for exactly the same reason that they should have any other kind of health insurance."

Signing up because you want to donate is not signing up for "exactly the same reason" as one has regular health insurance.

And I do not think everyone is in a financial position where they should donate money to cryonics research (or to anything).

For a younger American signing up for Alcor, the rough ballpark cost is 35 minutes of minimum wage work, 365 days a year. That's a big deal. That is a lot of one's life! Cost increases with age, so that's a minimum. (CI costs less than half that, which is still a lot of money for most people, and the quality drops along with the price.)

And I think if people have the means to make medical donations, SENS is a better option than cryonics. The SENS project you explain very well in Ending Aging, and elsewhere, makes a lot of sense and is a great idea, and you're working on it in a reasonable, competent, and effective way. Cryonics is an in-principle good idea, but unfortunately it doesn't go much further than that today. And I don't think throwing money at the issue will fix problems like some of the bad ideas of the people involved with Alcor and CI.

Example of what can happen with cryonics, not the patient's fault:

http://www.cryonics.org/case-reports/the-cryonics-institutes-95th-patient
Curtis deanimated under as favorable a set of circumstances as any of us could have hoped-for.
A number of CI Directors have become concerned that I have been modifying the cryoprotectant carrier solutions without adequate testing ... In response to concerns by CI Directors (and my own concerns) I will not make more modifications to the carrier solutions, and I believe we should return to using the traditional VM−1 carrier for the time being
Ben Best, CI president (at that time), was experimenting on people who paid to be preserved. The result was failure to perfuse with cryoprotectants. And this is written by the guilty party. For an outside perspective, Mike Darwin comments:

https://web.archive.org/web/20120406161301/http://chronopause.com/index.php/2011/02/23/does-personal-identity-survive-cryopreservation/
Even in cases that CI perfuses, things go horribly wrong – often – and usually for to me bizarre and unfathomable (and careless) reasons. My dear friend and mentor Curtis Henderson was little more than straight frozen because CI President Ben Best had this idea that adding polyethylene glycol to the CPA solution would inhibit edema. Now the thing is, Ben had been told by his own researchers that PEG was incompatible with DMSO containing solutions, and resulted in gel formation. Nevertheless, he decided he would try this out on Curtis Henderson. He did NOT do any bench experiments, or do test mixes of solutions, let alone any animal studies to validate that this approach would in fact help reduce edema (it doesn’t). Instead, he prepared a batch of this untested mixture, and AFTER it gelled, he tried to perfuse Curtis with it. ... Needless to say, as soon as he tried to perfuse this goop, perfusion came to a screeching halt. [In other CI cases,] They have pumped air into patient’s circulatory systems…
Ben Best and Mike Darwin discuss the matter further here:

http://lesswrong.com/lw/bk6/alcor_vs_cryonics_institute/6c35

Continue reading the next part of the discussion.

Elliot Temple | Permalink | Messages (0)

Aubrey de Grey Discussion, 1

I discussed epistemology and cryonics with Aubrey de Grey via email. Click here to find the rest of the discussion. Yellow-highlighted quotes are from Aubrey de Grey, with permission. Bluegreen highlights are me, red highlights are other quotes. The text with no highlights is me talking. I began the discussion like this:

You endorse Alcor and CI:

http://www.reddit.com/r/Futurology/comments/28e4v3/aubrey_de_grey_ama/cia3xn1?context=5
For the millionth time let me stress that referring to "getting older without getting sicker" as "becoming immortal" is not only inaccurate but actively counterproductive to this mission, because it entrenches the view of skeptics that the mission is quixotic. To answer the question you should have asked: obviously it depends on your age, but absolutely, everyone should have a life insurance policy with Alcor or Cryonics Institute, for exactly the same reason that they should have any other kind of health insurance.
Take a close look at Alcor and CI. While cryonics is a good idea in principle, Alcor and CI have lots of big problems (including that current cryonics technology isn't really good enough).

One big problem is not freezing people quickly. Max More, President and CEO of Alcor, writes:

http://lesswrong.com/lw/bk6/alcor_vs_cryonics_institute/69z7
You mention Mike Darwin, yet note that in Figure 11 of a recent analysis by him, he says that 48 percent of patients in Alcor's present population experienced "minimal ischemia." Of CI, Mike writes, "While this number is discouraging, it is spectacular when compared to the Cryonics Institute, where it is somewhere in the low single digits."
Alcor CEO brings up, favorably, a statistic meaning that Alcor does a bad job at least 52% of the time. Because, hey, CI does much worse, and the discussion topic is a comparison.

So I don't think you should tell people to sign up for CI and suggest it's the same quality as regular medicine.


You can find lots more information:

http://lesswrong.com/lw/bk6/alcor_vs_cryonics_institute/
http://lesswrong.com/lw/343/suspended_animation_inc_accused_of_incompetence/

(Comments include discussion from people like former Alcor President Mike Darwin.)

http://www.alcor.org/cases.html
http://www.cryonics.org/case-reports/

See e.g. the most recent CI case:

http://www.cryonics.org/case-reports/the-cryonics-institutes-123rd-patient
CI patient #123 was a 71 year old male from England. Due to the uncontrollable circumstances of this case, the patient was straight frozen without being perfused with cryoprotective solutions and was sent to the Cryonics Institute for long-term storage in liquid nitrogen.
They failed. As they often do. No cryoprotectants! And they don't care to provide details. And they indicate they won't do anything different in the future, since they consider whatever happened "uncontrollable".

The latest Alcor case is very problematic too:

http://www.alcor.org/Library/html/casesummary2680.html

They argued with a Medical Examiner for a while, then managed to get ahold of the body and began cool down 2.5 days after death. The delay sounds very worrisome to me, but the case report doesn't address this problem at all. No medical details are provided about how cool down went. And there's no explanation about what temperature the body was at for the 2.5 day delay, the resulting damage, and whether this person could reasonably be expected to ever be revived.

I like SENS. I like life. I like the idea of cryonics. But I wouldn't pay a bunch of money for the bad patient outcomes which CI and Alcor routinely provide (according even to their own claims on their websites).

Continue reading the next part of the discussion.

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Discussion with Aubrey de Grey

I discussed epistemology with Aubrey de Grey via email. The discussion focused on cryonics initially, but the majority is about epistemology. Epistemology is the field of philosophy that covers knowledge and learning.

Aubrey de Grey is the driving force behind SENS – Strategies for Engineered Negligible Senescence. What that means is organized and comprehensive medical research to deal with the problems caused by aging. If you donate money to any kind of charity, consider SENS.

If you're interested in SENS, read Aubrey de Grey's book Ending Aging. I read it and think it's a good book with good arguments (something I don't say lightly, as you can see by the critical scrutiny I've subjected Ann Coulter and others to.)

Click here to read the whole discussion. I made minor edits to remove a few irrelevant personal remarks and fix typos. Or click below for individual parts.

This discussion is now complete.

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Endorsements vs. Integrity

In a recent Center for Industrial Progress newsletter, Alex Epstein bragged about the prestigious people he'd gotten to sanction his upcoming book The Moral Case for Fossil Fuels.

Alex writes that they "endorsed" the book. I think that's accurate. They're siding with him. You understand.

One endorsement reads:
"Alex Epstein has written an eloquent and powerful argument for using fossil fuels on moral grounds alone. A remarkable book.”

--Matt Ridley, author of The Rational Optimist
Today I saw an article by Ridley about global warming. Note this is the same person from the book endorsement. His article takes roughly the same side as Epstein: it disagrees with the "settled science" of the "climate consensus" (scare quotes, not article quotes).

The article was OK, but at the end something stood out to me:
... concentrate on more pressing global problems like war, terror, disease, poverty, habitat loss and the 1.3 billion people with no electricity.
"[H]abitat loss" is not a pressing global problem in the same company as war, disease, etc...

This is not just my view. It's Epstein's view. Epstein disagrees with environmentalist views like this. He values people over animals. He's really strongly at odds with this kind of thinking.

Ridley endorsed Epstein's book, but actually disagrees in a huge way with Epstein's worldview.

What good are endorsements like that? Shouldn't Epstein reject endorsement by his philosophical opponents? Agreeing on a few particular conclusions about fossil fuels isn't enough. Epstein's book is fairly philosophical, and says he cares about about principles and philosophical reasoning (in line with his Objectivist philosophy). He shouldn't gloss over major philosophical differences to get dishonest but prestigious book promotion.

Elliot Temple | Permalink | Messages (0)